The Regional Unit of Phthiotis occupies the northeastern part of Central Greece and stretches from the slopes of southern Pindos to the shores of Maliakos and Euboea gulf. The region is geographically diverse, with mountains, coastal areas and plains. It is surrounded by the mountains of Othrios, Timfristos, Vardoussia, Iti, Kallidromon, Parnassos and Chlomo, and includes the plains of Domokos and Gorgopotamos. The main river of the region is Sperheios, which stems from the ravines of Timfristos and, after a 80km route, it flows into Maliakos Gulf. Phthiotis has a rich natural environment with forests, canyons, natural habitats and several hot springs. It also has many sights, ancient monuments, museums, monasteries and churches of the Byzantine and post-Byzantine period, and picturesque villages.
The city of Lamia is the administrative and commercial center of the prefecture and is also based in the region of Central Greece. Other important towns are Thermopylae, Kamena Vourla, Atalanti, Stylida and Ipati. The residents of Phthiotis are mainly occupied with agriculture, cattle breeding and fishing, producing excellent products. Also, important for the local economy are crafts, industry and the exploitation of mineral resources. The coast of the prefecture has a developed tourist infrastructure. Phthiotis is a transportation hub and is crossed by the national highway connecting Athens with Thessaloniki.